{"id":16170,"date":"2023-07-11T11:04:51","date_gmt":"2023-07-11T11:04:51","guid":{"rendered":"https:\/\/dekkbi.com\/?p=16170"},"modified":"2023-07-11T11:04:52","modified_gmt":"2023-07-11T11:04:52","slug":"avancee-revolutionnaire-de-luclouvain-dans-la-lutte-contre-le-rejet-de-greffes-dorgane","status":"publish","type":"post","link":"https:\/\/dekkbi.com\/?p=16170","title":{"rendered":"Avanc\u00e9e \u201cr\u00e9volutionnaire\u201d de l\u2019UCLouvain dans la lutte contre le rejet de greffes d\u2019organe"},"content":{"rendered":"\n<p><strong>Des chercheuses de l\u2019UCLouvain sont \u00e0 l\u2019origine d\u2019une avanc\u00e9e majeure dans la lutte contre le rejet des greffes d\u2019organe, a communiqu\u00e9 jeudi l\u2019universit\u00e9 de Louvain-la-Neuve.<\/strong><\/p>\n\n\n\n<p>Leur d\u00e9couverte \u201cr\u00e9volutionnaire\u201d a permis d\u2019identifier \u201cl\u2019un des facteurs majeurs\u201d de l\u2019\u00e9chec d\u2019une transplantation: le dosage inappropri\u00e9 du m\u00e9dicament anti-rejet, le tacrolimus, pr\u00e9cise l\u2019institution acad\u00e9mique. Par cons\u00e9quent, un meilleur ciblage du traitement post-greffe devrait \u201call\u00e9ger les effets secondaires qui en d\u00e9coulent\u201d. Les scientifiques, Laure Bindels et Laure Elens, \u00e9paul\u00e9es par Alexandra Degraeve, aspirante au Fonds de la recherche scientifique (FNRS), ont mis au jour les interactions entre la posologie du tacrolimus et le microbiote.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">Microbiote<\/h2>\n\n\n\n<p>\u00c0 la suite de leurs cinq ann\u00e9es d\u2019investigations, elles ont conclu que \u201cla pr\u00e9sence d\u2019un microbiote augmente la concentration du m\u00e9dicament dans le sang\u201d. Le microbiote peut donc diminuer \u201cle risque de rejet de greffes, ou, a contrario,\u201d augmenter \u201cle risque de survenue d\u2019effets secondaires\u201d en fonction des modalit\u00e9s de la prise du m\u00e9dicament, en ont d\u00e9duit les chercheuses.<\/p>\n\n\n\n<p>L\u2019\u00e9tude clinique \u201ca montr\u00e9 que plus le dosage du m\u00e9dicament est \u00e9lev\u00e9, moins le microbiote est riche (moins diversifi\u00e9 en bact\u00e9ries)\u201d, ajoute l\u2019UCLouvain. Selon l\u2019universit\u00e9, elle a aussi d\u00e9termin\u00e9 \u201cdeux genres de bact\u00e9ries sp\u00e9cifiques associ\u00e9es \u00e0 la diminution de la dose requise de tacrolimus\u201d.<\/p>\n\n\n\n<p>Gr\u00e2ce \u00e0 un financement du FNRS, les trois savantes vont \u00e9tudier d\u00e9sormais le microbiote sur une longue p\u00e9riode tandis que l\u2019exp\u00e9rimentation de leur concept \u201c\u00e0 d\u2019autres m\u00e9dicaments (anti-VIH, hypotenseurs, etc.)\u201d, est en cours, fait savoir leur employeur. En Belgique, environ 1.600 personnes sont en attente d\u2019une greffe chaque ann\u00e9e. D\u2019apr\u00e8s l\u2019UCLouvain, plus de 40% des patients doivent souvent patienter plus d\u2019un an avant d\u2019esp\u00e9rer \u00eatre transplant\u00e9s.<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Des chercheuses de l\u2019UCLouvain sont \u00e0 l\u2019origine d\u2019une avanc\u00e9e majeure dans la lutte contre le rejet des greffes d\u2019organe, a<\/p>\n","protected":false},"author":1,"featured_media":16173,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[5],"tags":[],"class_list":["post-16170","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-technologie"],"_links":{"self":[{"href":"https:\/\/dekkbi.com\/index.php?rest_route=\/wp\/v2\/posts\/16170","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/dekkbi.com\/index.php?rest_route=\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/dekkbi.com\/index.php?rest_route=\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/dekkbi.com\/index.php?rest_route=\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/dekkbi.com\/index.php?rest_route=%2Fwp%2Fv2%2Fcomments&post=16170"}],"version-history":[{"count":1,"href":"https:\/\/dekkbi.com\/index.php?rest_route=\/wp\/v2\/posts\/16170\/revisions"}],"predecessor-version":[{"id":16174,"href":"https:\/\/dekkbi.com\/index.php?rest_route=\/wp\/v2\/posts\/16170\/revisions\/16174"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/dekkbi.com\/index.php?rest_route=\/wp\/v2\/media\/16173"}],"wp:attachment":[{"href":"https:\/\/dekkbi.com\/index.php?rest_route=%2Fwp%2Fv2%2Fmedia&parent=16170"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/dekkbi.com\/index.php?rest_route=%2Fwp%2Fv2%2Fcategories&post=16170"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/dekkbi.com\/index.php?rest_route=%2Fwp%2Fv2%2Ftags&post=16170"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}